May  6 08:16:57 devbox spamc[16225]: connect to spamd on 127.0.0.1 failed, retrying (#2 of 3): Connection timed out
May  6 08:17:02 devbox spamc[20214]: connect to spamd on 127.0.0.1 failed, retrying (#1 of 3): Connection timed out
spamc[16225]: connect to spamd on 127.0.0.1 failed, retrying (#3 of 3): Connection timed out

First make sure that the spamd service is actually running, this is your spamd (spamassassin server) cannot be reached.  In my case it was, so what happened, why can't I connect?  I even restarted the service.

Then I realized that I setup a quick iptables script, one which didn't explicitly allow the spamd port to be contacted which is port 783.  Make sure the port is open otherwise you'll see these errors and you'll wonder where your e-mail went!